This page (together with the documents referred to on it) tells you the terms of use (terms) on which you may make use of our website https://predict-gi-risk-in-ida.com/ (our site). Please read these terms carefully before you start to use our site. By using our site, you are agreeing to these terms. If you do not agree to these terms, you must not use our site. We may change these terms at any time be amending this page. Please check this page every time you use our site to ensure you understand the terms that apply at that time. These terms were last updated on [1st December 2020].
https://predict-gi-risk-in-ida.com/ is a site operated by BU Innovations Limited (BUI/we/our/us) whose Company Number is 03708785 and registered office address is 2nd Floor, Melbury House, 1-3 Oxford Road, Bournemouth, BH8 8ES, UK. BUI a wholly owned subsidiary of Bournemouth University (BU).
Our site is made available free of charge. Our site is made available free of charge. We do not guarantee that our site, or any content on it, will always be available or be uninterrupted. We may suspend, withdraw or restrict availability of all or any part of our site without notice. We will try to give you reasonable notice of any suspension or withdrawal but we will not be liable if for any reason our site is unavailable at any time or for any period. From time to time, we may restrict access to some parts of our site, or our entire site, to any users.
Our site is for use by are healthcare professionals such as gastroenterologists, and specialist nurses. It is not intended for use by non-health professionals. The Predict GI Cancer in IDA app is a GI cancer risk predictive tool designed to be used with confirmed iron deficiency anaemia (IDA) patients prior to investigations. The app has only been formally validated using datasets from the population of the United Kingdom (UK). This risk prediction tool estimates the probability of GI cancer occurring without a guarantee that this GI cancer exists or will certainly occur. The app predicts the risk of GI cancer in patients with IDA merely based on four variables; age, sex, haemoglobin concentration (Hb), and mean cell volume (MCV). It does not adjust for other potential risk factors such as family history, previous cancer, race, unintentional weight loss, red meat consumption, alcohol or tobacco usage, etc. Predict GI Cancer in IDA cannot be used to predict GI cancer risk in any other patient group apart from adult patients with confirmed iron deficiency. The app is not intended to be used on patients who have been given iron replacement therapy prior to their blood testing as their Hb and MCV might be elevated by this therapy and might cause the app’s calculation, which relies on these blood markers values (Hb, MCV), to be unreliable. Additionally, the app is not intended to predict cancers other than GI cancers. The model does not claim to be the only method to Predict GI Cancer in IDA, nor does it preclude other methods to assess this risk.
The Predict GI Cancer in IDA app’s prediction model has been built by using anonymised clinical data for subjects in the UK referred for assessment in Poole Hospital NHS Foundation Trust’s IDA clinic with confirmed iron deficiency by standard laboratory criteria (transferrin saturation <15% and / or serum ferritin concentration less than the lower limit of the reference interval for the laboratory at the time) who were assessed between 2004 and 2018 inclusive. Cases presenting in 2004 – 2016 formed the training dataset (n=1879), whilst those presenting in 2017 – 2018 provided the validation dataset (n=511). Developing the model using the training dataset was carried out in 2018, before receiving the validation dataset. The final datasets included age at presentation and sex, blood test results (Hb, MCV and iron studies) and the diagnostic findings on standard investigation of the upper and lower GI tract. Datasets were complete for age, sex, Hb, MCV and presence / absence of GI cancer. The final prediction model in this app is based on the following mathematical formula of multiple binary logistic regression:
ln(GI cancer) ~ Β0 + Β1age + Β2sex + Β3Hb + Β4MCV.
Statistical assessment of validity and goodness of fit of the logistic regression model was satisfactory. Please refer to the research team’s publications to read more about the algorithm.
We are the owner or licensee of all intellectual property rights (registered and unregistered) in the design of our site, including its look and feel. All intellectual property rights in the content of our site, including any materials and applications, are protected by laws and treaties around the world. All such rights are reserved. We have taken all reasonable steps in developing our site and in obtaining all consents, permissions and waivers to enable us to present the material on it. Our site uses third party software which is licensed under the GNU General Public License (“GPL”) which requires us to provide copyright notices and/or additional terms and conditions to you. Such copyright notices and additional terms and conditions may be accessed by you at [https://www.gnu.org/licenses/gpl-3.0.html] and are incorporated by reference into these terms. Use, reproduction and distribution of the software licensed under the GPL are governed solely by the terms of that open source license and not these terms of use. You may print off one copy, and may download extracts, of any page(s) from our site for non-commercial, informational, educational and research purposes use only. You may not adapt, alter or create a derivative work from our site content except for any other purpose. You may draw the attention of others to content posted on our site. You must not use our site or any of the content of our site for commercial purposes. You must not modify the paper or digital copies of any materials you have printed off or downloaded in any way and you must not use any illustrations, photographs, video or audio sequences or any graphics separately from any accompanying text or marks. Our status (and that of any identified contributors) as authors of content on our site must always be acknowledged. Any names, images and logos identifying BUI, BU or third parties and mentioned, used or cited on our site are the property of their respective owners and are subject to copyright, design rights and/or trade marks of BUI, BU and/or third parties. Nothing contained in these terms shall be construed as conferring any licence or right to use any such names, images or logos. If you print off, copy or download any part of our site in breach of these terms, your right to use our site will cease immediately and you must, at our option, return or destroy any copies of the materials you have made.
Please read this section carefully as it sets out the limits of our liability to you in relation to your use of this site and the Predict GI Cancer in IDA app. As the software is governed by separate terms, you should also read the limits of liability described in the GPL. The contents of this site including without limitation, the prediction model, risk prediction results, numbers, text, links and all other materials are provided as a convenience to our app users and are non-commercial, informational, educational and research purposes only. Healthcare professionals should rely on their own independent clinical judgement and knowledge, relevant referral guidelines, and on assessing all the GI cancer risk factors including the factors which have not been considered in the app when taking any decision relating to the patient’s future clinical management. So you should not avoid further investigations following a prediction of a very low risk of GI cancer. Also, prediction of a high risk of GI cancer should not result in you fast-tracking the necessary investigations such as colonoscopy. Predict GI in IDA app is designed as an adjunct to standard counselling and personal discussion with a health care professional, and cannot replace it. All results are reference information only and must be interpreted in the context of each patient’s individual circumstances. The Predict GI in IDA app is not intended for use in the diagnosis of GI cancer or any other condition, or the cure, mitigation, treatment or prevention of disease in man, or other animals. We do not take responsibility for the decisions taken by the users based solely on the information provided in the Predict GI in IDA app. Although we make reasonable efforts to update the information on our site, we make no representations, warranties or guarantees, whether express or implied, that the content of our site is accurate, complete or up to date. We are not responsible for checking or updating material or links that we provide. If you use any information or materials on this site, you do so at your own risk. We are not liable for any loss you incur by using any of the information or materials available on our site. It is your responsibility to ensure before you use them that any information available through our site meets your specific needs. Nothing in these terms excludes or limits in any way our liability to you where it would be unlawful to do so. This includes liability for death or personal injury caused by our negligence or the negligence of our employees, agents or subcontractors and for fraud or fraudulent misrepresentation.
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We do not guarantee that our site or any material posted on it will be secure or free from bugs or viruses. You are responsible for configuring your information technology, computer programmes and platform to access our site. You should use your own virus protection software. You must not misuse our site by knowingly introducing viruses, trojans, worms, logic bombs or other material that is malicious or technologically harmful. You must not attempt to gain unauthorised access to our site, the server on which our site is stored or any server, computer or database connected to our site. You must not attack our site via a denial-of-service attack or a distributed denial-of service attack. By breaching this provision, you would commit a criminal offence under the Computer Misuse Act 1990. We will report any such breach to the relevant law enforcement authorities and we will co-operate with those authorities by disclosing your identity to them. In the event of such a breach, your right to use our site will cease immediately.
You may link to our home page, provided you do so in a way that is fair and legal and does not damage our reputation or take advantage of it, but you must not establish a link in such a way as to suggest any form of association, approval or endorsement on our part where none exists. You must not establish a link from a site which is not owned by you. Our site must not be framed on any other site, nor may you create a link to any part of our site other than the home page. We reserve the right to withdraw linking permission without notice. If you would like to make any use of material on our site other than that set out above, please contact IDIOM Research Team.
Where our site contains links to other sites and resources provided by third parties, these links are provided for your information only. Such links should not be interpreted as approval by us of those linked websites or information you may obtain from them. We have no control over the contents of those websites and resources and accept no responsibility for them or for any loss or damage that may arise from your use of them.
These terms of use, their subject matter and their formation, are governed by English law. Any case or action arising under these terms or the use of the Predict GI Cancer in IDA app shall be subject to the exclusive jurisdiction of the English courts.